Clinical Reviews
Psychiatric adverse reactions associated to new macrolides. Three case reports
Authors:
Sanz de Miguel MPa, Sancho Gracia Eb, Chapí Peña Bc, Romero Gil Rd, Campos Bernal Ae, García Vera Cf
aMIR Pediatría. Hospital Infantil Universitario Miguel Servet. Zaragoza. España.
bMIR Pediatría. Hospital Infantil Universitario Miguel Servet. Zaragoza. España.
cMIR Pediatría. Hospital Infantil Universitario Miguel Servet. Zaragoza. España.
dMIR Pediatría. Hospital Infantil Universitario Miguel Servet. Zaragoza. España.
eMIR Pediatría. Hospital Infantil Universitario Miguel Servet. Zaragoza. España.
fPediatra. Hospital Universitario Miguel Servet. CS Sagasta-Ruiseñores. Zaragoza. España.
Correspondence: MP Sanz. Email: pilarsdm@hotmail.com
Reference of this article.:
Sanz de Miguel MP, Sancho Gracia E, Chapí Peña B, Romero Gil R, Campos Bernal A, García Vera C. Reacciones adversas psiquiátricas asociadas a nuevos macrólidos. A propósito de tres casos. Rev Pediatr Aten Primaria. 2010;12:249-253.
Published in Internet: 30/06/2010
Abstract:
Macrolides represent the 10-15% of the world-wide market of oral antibiotics. They are one of the safer groups of antibiotics, being the severe adverse reactions very rare. They can produce gastrointestinal reactions, hepatotoxicity and ototoxicity. The psychiatric reactions are found sporadically among the adverse effects.
Cases reported to the FDA showed that clarithromycin and ciprofloxacin are the most frequent antibiotics associated with the development of mania. The syndrome has been termed antibiomania.
We present three clinical cases seen in a Primary Care office in the last year with similar pictures of hyperactivity and aggressiveness coinciding with the administration of antibiotics of the family of the macrolides.
Keywords: Macrolides. Adverse reaction. Mania.
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