What’s the clinical impact of using probiotics for infant colic?

Authors’ conclusions: although L. reuteri may be effective as a treatment strategy for crying in exclusively breastfed infants with colic, the evidence supporting probiotics use for the treatment of infant colic or crying in formula-fed infants remains unresolved. Results from larger rigorously designed studies will help draw more definitive conclusions.

Reviewers’ commentary: L. reuteri is useful in reducing the time of infant crying, reduces it an average of 55 minutes per day, but only in mothers under exclusive breastfeeding and cow milk protein-free diet. It is still premature to generalize these results, and it is not known if this strain will work in different populations or if it is cost-effective to give this treatment for 21 days.