Vol. 28 - Num. 112
Clinical Reviews
Thyrotoxic periodic paralysis, an underdiagnosed clinical challenge
Alicia Gaitero Péreza, Sara Martín Ucedab, Carmen Martínez del Ríob, María Abelaira Garcíac, Alejandro Parra Rodríguezd, Olga Pérez Rodríguezc
aServicio de Pediatría. Hospital Universitario 12 Octubre. Madrid. España.
bServicio de Pediatría. Hospital Clínico San Carlos. Madrid. España.
cMIR-Pediatría. Hospital Clínico San Carlos. Madrid. España.
dServicio de Pediatría. Hospital Universitario Fundación Jiménez Díaz. Madrid. España.
Correspondence: A Gaitero. E-mail: aligaitero@hotmail.com
Reference of this article: Gaitero Pérez A, Martín Uceda S, Martínez del Río C, Abelaira García M, Parra Rodríguez A, Pérez Rodríguez O. Thyrotoxic periodic paralysis, an underdiagnosed clinical challenge . Rev Pediatr Aten Primaria. 2026;28:[en prensa].
Published in Internet: 13-10-2026 - Visits: 80
Abstract
Thyrotoxic periodic paralysis (TPP) is a rare neurological disorder characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state. It is more common in Asian men (male-to-female ratio 50:1) during the third decade of life, but due to globalization, it is increasingly being diagnosed in continents other than Asia. Therefore, it is important to maintain a diagnostic suspicion in order to treat it correctly and prevent recurrences.
Keywords
● Graves’disease ● Hypokalemia ● Thyrotoxic periodic paralysis